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1

Molecular genetic testing for familial hypercholesterolemia: spectrum of LDL receptor gene mutations in the Netherlands

M Paola Lombardi, Egbert Jw Redeker, Joep C Defesche, Sylvia Wa Kamerling, Mieke D Trip, Marcel Mam Mannens, Louis M Havekes, John Jp Kastelein

Journal:

Clinical Genetics

Year:

2000

Language:

english

File:

PDF, 231 KB

english, 2000

2

Mutational and genetic origin of LDL receptor gene mutations detected in both Belgian and Dutch familial hypercholesterolemics

A. V. Peeters, Luc F. Van Gaal, L. du Plessis, M. Paola R. Lombardi, Louis M. Havekes, Maritha J. Kotze

Journal:

Year:

1997

Language:

english

File:

PDF, 62 KB

english, 1997

3

A low-fat diet has a higher potential than energy restriction to improve high-fat diet-induced insulin resistance in mice

Martin Muurling, Miek C. Jong, Ronald P. Mensink, Gerard Hornstra, Vivian E.H. Dahlmans, Hanno Pijl, Peter J. Voshol, Louis M. Havekes

Journal:

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

4

Raman spectroscopic investigation of atorvastatin, amlodipine, and both on atherosclerotic plaque development in APOE*3 Leiden transgenic mice

Sweder W.E van de Poll, Dianne J.M Delsing, J.Wouter Jukema, Hans M.G Princen, Louis M Havekes, Gerwin J Puppels, Arnoud van der Laarse

Journal:

Atherosclerosis

Year:

2002

Language:

english

File:

PDF, 162 KB

english, 2002

5

A Novel EPO Receptor Agonist Improves Glucose Tolerance via Glucose Uptake in Skeletal Muscle in a Mouse Model of Diabetes

Scully, Michael S., Ort, Tatiana A., James, Ian E., Bugelski, Peter J., Makropoulos, Dorie A., Deutsch, Heather A., Pieterman, Elsbet J., van den Hoek, Anita M., Havekes, Louis M., duBell, William H.,

Journal:

Experimental Diabetes Research

Year:

2011

Language:

english

File:

PDF, 1.27 MB

english, 2011

6

Increased Hepatic Insulin Sensitivity Together with Decreased Hepatic Triglyceride Stores in Hormone-Sensitive Lipase-Deficient Mice

Voshol, Peter J., Haemmerle, Guenter, Ouwens, D. Margriet, Zimmermann, Robert, Zechner, Rudolf, Teusink, Bas, Maassen, J. Antonie, Havekes, Louis M., Romijn, Johannes A.

Journal:

Year:

2003

Language:

english

File:

PDF, 237 KB

english, 2003

7

Gut???brain axis

Romijn, Johannes A, Corssmit, Eleonora P, Havekes, Louis M, Pijl, Hanno

Journal:

Current Opinion in Clinical Nutrition & Metabolic Care

Year:

2008

Language:

english

File:

PDF, 161 KB

english, 2008

8

The apolipoprotein E ε2 allele is associated with an increased risk of early-onset alzheimer's disease and a reduced survival

Cornelia M. van Duijn, Peter de Knijff, Anita Wehnert, Joke De Voecht, Juliana B. Bronzova, Louis M. Havekes, Albert Hofman, Dr Christine van Broeckhoven

Journal:

Annals of Neurology

Year:

1995

Language:

english

File:

PDF, 652 KB

english, 1995

9

Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis

Willem F. Nieuwenhuizen, Ilse Duivenvoorden, Peter J. Voshol, Patrick C. N. Rensen, Wim van Duyvenvoorde, Johannes A. Romijn, Jef J. Emeis, Louis M. Havekes

Journal:

European Journal of Lipid Science and Technology

Year:

2007

Language:

english

File:

PDF, 256 KB

english, 2007

10

Regulation of low density lipoprotein receptor activity in primary cultures of human hepatocytes by serum lipoproteins

Louis M. Havekes, Hans Verboom, Elly de Wit, Sing Hiem Yap, Hans M. G. Princen

Journal:

Year:

1986

Language:

english

File:

PDF, 634 KB

english, 1986

11

Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels

Peter de Knijff, Arn M. J. M. van den Maagdenberg, Rune R. Frants, Louis M. Havekes

Journal:

Year:

1994

Language:

english

File:

PDF, 1.64 MB

english, 1994

12

Calcium-mediated regulation of the low density lipoprotein receptor and intracellular cholesterol synthesis in human epidermal keratinocytes

Maria Ponec, Louis Havekes, Johanna Kempenaar, Sjan Lavrijsen, Marian Wijsman, Johannes Boonstra, Bert Jan Vermeer

Journal:

Journal of Cellular Physiology

Year:

1985

Language:

english

File:

PDF, 1005 KB

english, 1985

13

Specific and efficient targeting of adenovirus vectors to macrophages: application of a fusion protein between an adenovirus-binding fragment and avidin, linked to a biotinylated oligonucleotide

J. C. Emile Gras, Paul Verkuijlen, Rune R. Frants, Louis M. Havekes, Theo J. C. van Berkel, Erik A. L. Biessen, K. Willems van Dijk

Journal:

The Journal of Gene Medicine

Year:

2006

Language:

english

File:

PDF, 704 KB

english, 2006

14

High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance

Johan De Vogel-van den Bosch, Sjoerd A.A. van den Berg, Silvia Bijland, Peter J. Voshol, Louis M. Havekes, Hans A. Romijn, Joris Hoeks, Denis van Beurden, Matthijs K.C. Hesselink, Patrick Schrauwen, K

Journal:

The Journal of Nutritional Biochemistry

Year:

2011

Language:

english

File:

PDF, 495 KB

english, 2011

15

Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins

Jolanda MA Boer, Jan Albert Kuivenhoven, Edith JM Feskens, Evert G Schouten, Louis M Havekes, Jacob C Seidell, John JP Kastelein, Daan Kromhout

Journal:

Clinical Genetics

Year:

1999

Language:

english

File:

PDF, 234 KB

english, 1999

16

Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

Mei Wang, Robert-Jan A. N. Lamers, Henrie A. A. J. Korthout, Joop H. J. van Nesselrooij, Renger F. Witkamp, Rob van der Heijden, Peter J. Voshol, Louis M. Havekes, Rob Verpoorte, Jan van der Greef

Journal:

Phytotherapy Research

Year:

2005

Language:

english

File:

PDF, 552 KB

english, 2005

17

Identification of a splice-site mutation in the low density lipoprotein receptor gene by denaturing gradient gel electrophoresis

Bert Top, André Zee, Louis M. Havekes, Ferdinand M. Hooft, Rune R. Frants

Journal:

Year:

1993

Language:

english

File:

PDF, 654 KB

english, 1993

18

The effect of the apolipoprotein E phenotype on plasma lipids is not influenced by environmental variability: results of a Dutch twin study

Peter Knijff, Dorret I. Boomsma, Elly Wit, Herman Jan M. Kempen, Jan A. Gevers Leuven, Rune R. Frants, Louis M. Havekes

Journal:

Year:

1993

Language:

english

File:

PDF, 529 KB

english, 1993

19

Conjugation deficientE. coliK12 F-mutants with heptose-less lipopolysaccharide

Louis M. Havekes, Ben J. J. Lugtenberg, Wiel P. M. Hoekstra

Journal:

Molecular Genetics and Genomics

Year:

1976

Language:

english

File:

PDF, 754 KB

english, 1976

20

meoAis the structural gene for outer membrane protein c ofEscherichia coliK12

Loek Alphen, Ben Lugtenberg, Ria Boxtel, Anne-Marie Hack, Cornelis Verhoef, Louis Havekes

Journal:

Molecular Genetics and Genomics

Year:

1979

Language:

english

File:

PDF, 1.46 MB

english, 1979

21

Apolipoprotein gene cluster on chromosome 19

Marijke Smit, Ellien Kooij-Meijs, Rune R. Frants, Louis Havekes, Eduard C. Klasen

Journal:

Year:

1988

Language:

english

File:

PDF, 707 KB

english, 1988

22

Relation between F, R1, R100 and R144Escherichia coliK-12 donor strains in mating

Louis Havekes, Wiel Hoekstra, Han Kempen

Journal:

Molecular Genetics and Genomics

Year:

1977

Language:

english

File:

PDF, 451 KB

english, 1977

23

Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease

Juliana Bronzova, Cornelia M. Duijn, Louis M. Havekes, Peter Knijff, Christine Broeckhoven, Albert Hofman

Journal:

Journal of Neurology

Year:

1996

Language:

english

File:

PDF, 405 KB

english, 1996

24

Apolipoprotein E polymorphism in the Netherlands and its effect on plasma lipid and apolipoprotein levels

Marijke Smit, Peter de Knijff, Maryvonne Rosseneu, Jo Bury, Eduard Klasen, Rune Frants, Louis Havekes

Journal:

Year:

1988

Language:

english

File:

PDF, 680 KB

english, 1988

25

Plasma apolipoprotein CI correlates with increased survival in patients with severe sepsis

Jimmy F. P. Berbée, Caroline C. van der Hoogt, Carla J. C. de Haas, Kok P. M. van Kessel, Geesje M. Dallinga-Thie, Johannes A. Romijn, Louis M. Havekes, Henk J. van Leeuwen, Patrick C. N. Rensen

Journal:

Intensive Care Medicine

Year:

2008

Language:

english

File:

PDF, 175 KB

english, 2008

26

Preoperative apolipoprotein CI levels correlate positively with the proinflammatory response in patients experiencing endotoxemia following elective cardiac surgery

Emile F. Schippers, Jimmy F. P. Berbée, Inge M. van Disseldorp, Michael I. M. Versteegh, Louis M. Havekes, Patrick C. N. Rensen, Jaap T. van Dissel

Journal:

Intensive Care Medicine

Year:

2008

Language:

english

File:

PDF, 229 KB

english, 2008

27

The T705I mutation of the low density lipoprotein receptor gene (FH Paris-9) does not cause familial hypercholesterolemia

P. Lombardi, Eric J. G. Sijbrands, Sylvia Kamerling, Jan A. Gevers Leuven, Louis M. Havekes

Journal:

Year:

1996

Language:

english

File:

PDF, 116 KB

english, 1996

28

Local Cre-Mediated Gene Recombination in Vascular Smooth Muscle Cells in Mice

Susanne M. Zadelaar, Lianne S. M. Boesten, Nuno M. M. Pires, Anita van Nieuwkoop, Erik A. L. Biessen, Wouter Jukema, Louis M. Havekes, Bart J. M. van Vlijmen, Ko Willems van Dijk

Journal:

Transgenic Research

Year:

2006

Language:

english

File:

PDF, 310 KB

english, 2006

29

Dissection of the complex role of apolipoprotein E in lipoprotein metabolism and atherosclerosis using mouse models

Ko Willems van Dijk, Marten H. Hofker, Louis M. Havekes

Journal:

Current Atherosclerosis Reports

Year:

1999

Language:

english

File:

PDF, 270 KB

english, 1999

30

Defective Low-Density Lipoprotein Metabolism in Cultured, Normal, Transformed, and Malignant Keratinocytes.

Ponec, Maria, Havekes, Louis, Kempenaar, Johanna, Lavrijsen, Sjan, Vermeer, Bert Jan

Journal:

The Journal of Investigative Dermatology

Year:

1984

File:

PDF, 2.15 MB

1984

31

SV 40-Transformed (SVK14) and Normal Keratinocytes: Similarity in the Expression of Low-Density Lipoprotein, Epidermal Growth Factor, Glucocorticoid Recepotrs, and the Regulation of Lipid Metabolism.

Ponec, Maria, Lavrijsen, Sjan, Kempenaar, Johanna, Havekes, Louis, Boonstra, Johannes

Journal:

The Journal of Investigative Dermatology

Year:

1985

File:

PDF, 2.81 MB

1985

32

Familial Dysbetalipoproteinemia: A Genetically Heterogeneous Disease Caused by Mutations of the Ligand Apolipoprotein E.

Vermeer, Bert Jan, Frants, Rune R., Havekes, Louis M.

Journal:

The Journal of Investigative Dermatology

Year:

1992

File:

PDF, 2.15 MB

1992

33

LDL Receptors in Keratinocytes.

Ponec, Maria, te Pas, Marinus F.W., Havekes, Louis, Boonstra, Johannes, Mommaas, A. Mieke, Vermeer, Bert Jan

Journal:

The Journal of Investigative Dermatology

Year:

1992

File:

PDF, 3.97 MB

1992

34

Regulation of Low-Density Lipoprotein Receptor Expression During Keratinocyte Differentiation.

F.W. Te Pas, Marinus, Paola Lombardi,, Louis M. Havekes,, Johannes Boonstra,, Maria Ponec,

Journal:

The Journal of Investigative Dermatology

Year:

1991

File:

PDF, 2.84 MB

1991

35

Cultured Human Skin Fibroblasts and Keratinocytes: Differences in the Regulation of Cholesterol Synthesis.

Ponec, Maria, Havekes, Louis, Kempenaar, Johanna, Jan Vermeer, Bert

Journal:

The Journal of Investigative Dermatology

Year:

1983

File:

PDF, 3.65 MB

1983

36

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice

Niels Bovenschen, Ko Willems van Dijk, Louis M. Havekes, Koen Mertens, Bart J. M. van Vlijmen

Journal:

British Journal of Haematology

Year:

2004

Language:

english

File:

PDF, 155 KB

english, 2004

37

The expression of type III hyperlipoproteinemia: involvement of lipolysis genes

Henneman, Peter, van der Sman-de Beer, Femke, Moghaddam, Payman Hanifi, Huijts, Petra, Stalenhoef, Anton FH, Kastelein, John JP, van Duijn, Cornelia M, Havekes, Louis M, Frants, Rune R, van Dijk, Ko W

Journal:

European Journal of Human Genetics

Year:

2008

Language:

english

File:

PDF, 183 KB

english, 2008

38

Apolipoprotein E Protects against Neuropathology Induced by a High-Fat Diet and Maintains the Integrity of the Blood-Brain Barrier during Aging

Mulder, Monique, Blokland, Arjan, van den Berg, Dirk-Jan, Schulten, Henny, Bakker, Arjen H F, Terwel, Dick, Honig, Wiel, de Kloet, E Ronald, Havekes, Louis M, Steinbusch, Harry W M

Journal:

Laboratory Investigation

Year:

2001

Language:

english

File:

PDF, 407 KB

english, 2001

39

Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease

van Duijn, Cornelia M., de Knijff, Peter, Cruts, Marc, Wehnert, Anita, Havekes, Louis M., Hofman, Albert, Broeckhoven, Christine Van

Journal:

Nature Genetics

Year:

1994

File:

PDF, 513 KB

1994

40

Development of Atopic Dermatitis in Mice Transgenic for Human Apolipoprotein C1

Nagelkerken, Lex, Verzaal, Perry, Lagerweij, Tonny, Persoon-Deen, Carla, Berbee, Jimmy F P, Prens, Errol P, Havekes, Louis M, Oranje, Arnold P

Journal:

The Journal of Investigative Dermatology

Year:

2007

Language:

english

File:

PDF, 943 KB

english, 2007

41

Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis

Paul J. Tacken, Andre van der Zee, Tim L. Beumer, Ralph J. Florijn, Marion J. J. Gijpels, Louis M. Havekes, Rune R. Frants, Ko Willems van Dijk, Marten H. Hofker

Journal:

Transgenic Research

Year:

2001

Language:

english

File:

PDF, 197 KB

english, 2001

42

Intestinal lipid absorption is not affected in CD36 deficient mice

Jeltje R. Goudriaan, Vivian E.H. Dahlmans, Maria Febbraio, Bas Teusink, Johannes A. Romijn, Louis M. Havekes, Peter J. Voshol

Journal:

Molecular and Cellular Biochemistry

Year:

2002

Language:

english

File:

PDF, 86 KB

english, 2002

43

High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice

Sjoerd A.A. van den Berg, Miranda Nabben, Silvia Bijland, Peter J. Voshol, Jan Bert van Klinken, Louis M. Havekes, Johannes A. Romijn, Joris Hoeks, Matthijs K. Hesselink, Patrick Schrauwen, Ko Willems

Journal:

Year:

2010

Language:

english

File:

PDF, 282 KB

english, 2010

44

P40—Perfluorohexanesulfonate and perfluorooctanesulfonate decrease plasma cholesterol and triglycerides in APOE*3LEIDEN.CETP mice by reducing VLDL production and increasing VLDL and HDL clearance

Elsbet J. Pieterman, Patrick C.N. Rensen, Annemarie C.E. Maas, José W.A. van der Hoorn, Louis M. Havekes, David J. Ehresman, Shu-Ching Chang, John L. Butenhoff, Hans M.G. Princen

Journal:

Reproductive Toxicology

Year:

2012

Language:

english

File:

PDF, 109 KB

english, 2012

45

Macrophage P53 controls foam cell death in atherosclerotic lesions of apolipoprotein E deficient mice

Marion J.J. Gijbels, Lianne S.M. Boesten, A. Suzanne M. Zadelaar, Aart G. Jochemsen, Bob van de Water, Bart J.M. van Vlijmen, Louis M. Havekes, Menno P.J. de Winther

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 52 KB

english, 2006

46

Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in mice

Lihui Hu, Jouke T. Tamsma, Lianne S.M. Boesten, Petra May, Joachim Herz, Niels Bovenschen, Menno V. Huisman, Jimmy F.P. Berbee, Louis M. Havekes, Bart J.M. van Vlijmen

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 51 KB

english, 2006

47

The effect of maternal hypercholesterolemia on vascular differentiation and fetal plasma cholesterol levels

Fanneke E. Alkemade, Marco C. DeRuiter, Ko Willems van Dijk, Conny J. VanMunsteren, Louis M. Havekes, Adriana C. Gittenberger-de Groot

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 63 KB

english, 2006

48

Clearance of plasminogen activator inhibitor-1 in low-density lipoprotein receptor-related protein deficient mice

Lihui Hu, Bart J.M. van Vlijmen, Niels Bovenschen, Menno V. Huisman, Louis M. Havekes, Jouke T. Tamsma

Journal:

Vascular Pharmacology

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

49

HOE 402 lowers serum cholesterol levels by reducing VLDL-lipid production, and not by induction of the LDL receptor, and reduces atherosclerosis in wild-type and LDL receptor-deficient mice

Richard Draijer, Oscar L. Volger, Vivian E.H. Dahlmans, Elly C.M. de Wit, Louis M. Havekes, Hans M.G. Princen

Journal:

Biochemical Pharmacology

Year:

2002

Language:

english

File:

PDF, 177 KB

english, 2002

50

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

Melly S. Oitzl, Monique Mulder, Paul J. Lucassen, Louis M. Havekes, Jeannette Grootendorst, E.Ron de Kloet

Journal:

Year:

1997

Language:

english

File:

PDF, 894 KB

english, 1997

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